SKRININIG FITOKIMIA ASHITABA (Angelica keskei) TERHADAP ENOIL ACP REDUKTASE (inhA) Mycobacterium tuberculosis SEBAGAI SENYAWA POTENSIAL ANTI-TB
نویسندگان
چکیده
Tuberkulosis (TB) merupakan penyakit menular yang telah menginfeksi seperempat populasi dunia. Isoniazid adalah obat pilihan pertama untuk mengobati TB dengan mekanisme menghambat enoil ACP reductase (inhA) berperan penting dalam sintesis dinding sel M. tuberculosis. Akan tetapi, penggunaan isoniazid jangka relatif panjang dapat menghasilkan efek hepatotoksik sehingga diperlukan pengembangan anti-TB baru. Ekstrak ashitaba dilaporkan memiliki aktivitas anti-TB. Oleh karena itu, penelitiaan ini dilakukan menemukan senyawa aktif bertanggung jawab terhadap secara in siliko reseptor inhA. Metode penambatan molekul menggunakan perangkat lunak Autodock tools 1.5.6. Hasil menunjukkan dari 40 fitokimia diuji, terdapat 8 nilai energi ikatan bebas dan konstanta inhibisi lebih baik ligan alami aktif, yaitu iakatan kecil aktif. Senyawa prostratol F xantoangelol I 2 terbaik interaksi mirip potensial dikembangkan menjadi
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ژورنال
عنوان ژورنال: Indonesia natural research pharmaceutical journal
سال: 2022
ISSN: ['2502-8421']
DOI: https://doi.org/10.52447/inrpj.v7i1.5481